Which statement describes pepsinogen?

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Multiple Choice

Which statement describes pepsinogen?

Explanation:
Pepsinogen is an inactive precursor (a zymogen) produced by the stomach’s chief cells. It is released into the stomach lumen in this inactive form and is activated to pepsin in the highly acidic environment of gastric juice. This activation is autocatalytic: a small amount of pepsin formed from pepsinogen helps convert more pepsinogen into pepsin. The reason this matters is it protects the stomach lining from digestion until the enzyme is properly activated. The other descriptions don’t fit: pepsinogen is not an active enzyme nor produced by parietal cells (they secrete acid and intrinsic factor), it is not a component of mucus, and it is not a hormone.

Pepsinogen is an inactive precursor (a zymogen) produced by the stomach’s chief cells. It is released into the stomach lumen in this inactive form and is activated to pepsin in the highly acidic environment of gastric juice. This activation is autocatalytic: a small amount of pepsin formed from pepsinogen helps convert more pepsinogen into pepsin. The reason this matters is it protects the stomach lining from digestion until the enzyme is properly activated.

The other descriptions don’t fit: pepsinogen is not an active enzyme nor produced by parietal cells (they secrete acid and intrinsic factor), it is not a component of mucus, and it is not a hormone.

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